Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.60 |
| ▸ | GHSR | Q92847 | 2/20 | 0.60 |
| ▸ | CCKBR | P32239 | 1/20 | 0.60 |
| ▸ | MC3R | P41968 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312295 | 0.84 | GABRG2 (0.54) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL11509824 | 0.83 | GABRA1 (0.62) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL11829978 | 0.79 | GABRA1 (0.64) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL11835237 | 0.77 | GABRA1 (0.64) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL11828371 | 0.76 | GABRA1 (0.60) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL11509319 | 0.76 | GABRA1 (0.51) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL44169 | 0.75 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL29902314 | 0.75 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL8812488 | 0.75 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL29372584 | 0.75 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4368157-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368158-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368159-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |