Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11165367 | 0.91 | ALDH1A1 (0.58) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11169713 | 0.90 | ALDH1A1 (0.57) | ALDH1A1RECQLSMN1; SMN2SLC6A4GAA | |
| SCHEMBL11596000 | 0.86 | ALDH1A1 (0.62) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11169141 | 0.82 | ALDH1A1 (0.62) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11169969 | 0.82 | ALDH1A1 (0.59) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11170337 | 0.80 | ALDH1A1 (0.74) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11158648 | 0.77 | AKR1B1 (0.59) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL11156811 | 0.73 | ALDH1A1 (0.58) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 | |
| SCHEMBL10731198 | 0.72 | CYP1A2 (0.74) | ALDH1A1RECQLSMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL5011797 | 0.70 | SLC6A4 (0.58) | ALDH1A1RECQLSMN1; SMN2AKR1B1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4393062-A | ALDOSE REDUCTASE INHIBITOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-12 | — | — | US | disclosed |
| EP-0002895-B1 | ENZYME INHIBITORY PHTHALAZIN-4-YLACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESS FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-10-14 | — | — | EP | disclosed |
| US-4251528-A | ALDOSE REDUCTASE INHIBITORS USEFUL IN DIABETES, GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |