Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11172659 | 0.85 | JAK2 (0.43) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL11161587 | 0.84 | HAVCR2 (0.50) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL11082274 | 0.84 | HAVCR2 (0.47) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL11163916 | 0.82 | JAK2 (0.47) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL8376736 | 0.81 | JAK2 (0.44) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL8375789 | 0.81 | CA12 (0.48) | HAVCR2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL10922730 | 0.81 | GABRP (0.60) | HAVCR2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL11164556 | 0.81 | JAK2 (0.46) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL11085427 | 0.80 | HAVCR2 (0.48) | HAVCR2JAK2PAK4NTRK1LCK | |
| SCHEMBL8375791 | 0.80 | PARP1 (0.41) | HAVCR2HSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080176-A1 | Triazoloquinazolines, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1983-06-01 | — | — | EP | disclosed |