Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.77 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.77 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.77 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.77 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.77 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.55 |
| ▸ | CFB | P00751 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020019 | 0.87 | ADRA2A (1.00) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11165537 | 0.82 | ADRA2A (0.60) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11160978 | 0.82 | ADRA2A (0.69) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11159084 | 0.82 | ADRA2A (0.59) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11160707 | 0.82 | ADRA2A (0.59) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11161109 | 0.82 | ADRA2A (0.60) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL1741885 | 0.81 | ADRA2A (0.77) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11161510 | 0.81 | ADRA2A (0.76) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11162465 | 0.81 | ADRA2A (0.58) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL11160952 | 0.79 | ADRA2A (0.68) | ADRA1AADRA2AADRA2CADRA2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |