Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11165377 | 0.75 | SMN1; SMN2 (0.47) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL11197061 | 0.70 | OPRD1 (0.46) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL14825407 | 0.70 | OPRD1 (0.55) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL3391962 | 0.69 | CACNA2D1 (0.61) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL11172581 | 0.68 | ATM (0.50) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL9272210 | 0.67 | CYP3A4 (0.48) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| Hydrochloric Acid SCHEMBL11162041 | 0.67 | ATM (0.49) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL14825846 | 0.67 | OPRD1 (0.51) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| Hydrochloric Acid SCHEMBL9775427 | 0.67 | LMNA (0.60) | ATMOPRD1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL14825403 | 0.66 | OPRD1 (0.58) | ATMOPRD1SMN1; SMN2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0032058-B1 | THIAZOLE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-10-26 | — | — | EP | disclosed |
| EP-0032058-A1 | Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-07-15 | — | — | EP | disclosed |