Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 13/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770594 | 0.94 | PIK3CG (0.40) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL798617 | 0.85 | PIK3CG (0.49) | PIK3CGPIK3CALMNAHPGDGAA | |
| SCHEMBL12598915 | 0.84 | TSHR (0.43) | LMNAMAPTALDH1A1NPC1TP53 | |
| SCHEMBL2144189 | 0.84 | ALDH1A1 (0.50) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL1770505 | 0.83 | ALDH1A1 (0.39) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL3273615 | 0.83 | LMNA (0.39) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL2690333 | 0.82 | PIK3CG (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL1770199 | 0.82 | ALDH1A1 (0.39) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL2691580 | 0.82 | LMNA (0.42) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL12598910 | 0.81 | ALDH1A1 (0.39) | PIK3CGPIK3CAPIK3CDPIK3CBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304556-B2 | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| EP-2280982-A1 | THIAZOLYL-DIHYDRO-INDAZOLES | Boehringer Ingelheim International GmbH (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009112565-A1 | THIAZOLYL-DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | PIK3CG 4280/4885PIK3CA 2993/4885PIK3CD 3523/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | PIK3CG 4280/4885PIK3CA 2993/4885PIK3CD 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.