Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11187665 | 0.91 | ADRB2 (0.44) | CYP2D6ADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL11187559 | 0.91 | KMT2A (0.49) | CYP2D6ADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL11192850 | 0.90 | SLC6A4 (0.46) | CYP2D6ADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL11190574 | 0.88 | ADRB2 (0.55) | CYP2D6ADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL11189748 | 0.88 | MTNR1A (0.47) | CYP2D6ADRB2ADRB1ADRB3MTNR1A | |
| SCHEMBL11180497 | 0.88 | CASR (0.50) | CYP2D6ADRB2ADRB1ADRB3TSHR | |
| SCHEMBL11191954 | 0.87 | ADRB3 (0.47) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL11187082 | 0.87 | SLC6A4 (0.49) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL5307465 | 0.84 | SLC6A4 (0.49) | CYP2D6 | |
| SCHEMBL11184624 | 0.82 | ADRB2 (0.55) | CYP2D6ADRB2ADRB1ADRB3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341718-A | α-[(Alkylamino)-methyl]-β-aryloxy-benzeneethanols exhibiting antiarrhythmic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-07-27 | — | — | US | claimed |
| US-4401832-A | REACTING ALKALI METAL ARYLOXIDE WITH PHENYL-2-OXIRANECARBOXAMIDE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-08-30 | — | — | US | disclosed |
| US-4341718-A | α-[(Alkylamino)-methyl]-β-aryloxy-benzeneethanols exhibiting antiarrhythmic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-07-27 | — | — | US | disclosed |