Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243767 | 0.78 | LMNA (0.47) | HSP90AA1SMN1; SMN2CASP3SENP8SENP7 | |
| SCHEMBL16410073 | 0.76 | HSP90AA1 (0.73) | ESR1ESR2HSP90AA1SMN1; SMN2CASP3 | |
| SCHEMBL15428680 | 0.74 | DPP4 (0.42) | L3MBTL1 | |
| SCHEMBL10478055 | 0.74 | MEN1 (0.39) | SMN1; SMN2CASP3SENP8SENP7SENP6 | |
| SCHEMBL14261867 | 0.69 | ESR1 (0.72) | ESR1ESR2HSP90AA1SMN1; SMN2CASP3 | |
| SCHEMBL15775761 | 0.69 | ESR1 (0.41) | ESR1ESR2HSP90AA1SMN1; SMN2ALOX15 | |
| SCHEMBL2068581 | 0.66 | ALDH1A1 (0.68) | SMN1; SMN2ALOX15TSHRBRD4NR1I2 | |
| SCHEMBL5730461 | 0.66 | ESR1 (0.53) | ESR1ESR2HSP90AA1SMN1; SMN2CASP3 | |
| SCHEMBL14578987 | 0.65 | ALDH1A1 (0.65) | SMN1; SMN2ALOX15TSHRBRD4NR1I2 | |
| SCHEMBL4083689 | 0.65 | ALDH1A1 (0.52) | ESR1ESR2SMN1; SMN2CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4350815-A | REACTING 3-AMINO-2,4-DICYANOCROTONIC ACID METHYL ESTER WITH A BENZOHYDROXYAMINO ACID CHLORIDE | LONZA LTD. (CH) | 1982-09-21 | — | — | US | claimed |
| US-4387231-A | CHEMICAL INTERMEDIATE IN PRODUCTION OF 4,6-DIAMINO-K-CYANO-3-PHENYL-ISOXAZOLE(5,4-B)-PYRIDINE | LONZA LTD. (CH) | 1983-06-07 | — | — | US | disclosed |
| US-4376862-A | INTERMEDIATE FOR ISOXAZOLO (5,4B) PYRIDINE | LONZA LTD. (CH) | 1983-03-15 | — | — | US | disclosed |
| US-4350815-A | REACTING 3-AMINO-2,4-DICYANOCROTONIC ACID METHYL ESTER WITH A BENZOHYDROXYAMINO ACID CHLORIDE | LONZA LTD. (CH) | 1982-09-21 | — | — | US | disclosed |
| US-4350816-A | REACTING 3-AMINO-2,4-DICYANOCROTONIC ACID METHYL ESTER WITH A BENZOHYDROXYAMINO ACID CHLORIDE | LONZA LTD. (CH) | 1982-09-21 | — | — | US | disclosed |