Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11193815 | 0.82 | DNMT1 (0.37) | PTAFRDPP4SMARCA2DNMT1RAD52 | |
| SCHEMBL11829561 | 0.81 | PTAFR (0.48) | PTAFRHDAC4HDAC8HDAC5SMARCA2 | |
| SCHEMBL10365364 | 0.78 | TOP2A (0.47) | PTAFRALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL16869399 | 0.75 | TOP2A (0.54) | — | |
| SCHEMBL11187693 | 0.73 | KDM4E (0.38) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL11190925 | 0.73 | MAPT (0.45) | MAOBALDH1A1NPC1LMNARAB9A | |
| SCHEMBL11180683 | 0.71 | ADRA2B (0.46) | LMNA | |
| Hydrochloric Acid SCHEMBL11195804 | 0.70 | NPSR1 (0.50) | ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL11192478 | 0.70 | TOP2A (0.46) | PTAFR | |
| SCHEMBL11188706 | 0.70 | PTAFR (0.46) | PTAFRHDAC4HDAC8HDAC5DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420619-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0004561-B1 | UREA AND AMIDE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICALS CONTAINING THEM AND THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS | CIBA-GEIGY AG (CH) | 1981-11-04 | — | — | EP | disclosed |
| US-4292429-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
| EP-0004561-A2 | Urea and amide derivatives, their preparation, pharmaceuticals containing them and their use for preparing pharmaceutical compositions | CIBA-GEIGY AG (CH) | 1979-10-17 | — | — | EP | disclosed |