Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11187929 | 0.85 | CYP2D6 (0.37) | ADRA2BADRA2CMEN1KMT2ACYP1A2 | |
| SCHEMBL11189671 | 0.81 | CYP1A2 (0.46) | CYP1A2CYP2D6KDM4E | |
| SCHEMBL11186437 | 0.78 | MEN1 (0.37) | MEN1KMT2ACYP1A2CYP2D6GAA | |
| SCHEMBL11180678 | 0.76 | ADRA2B (0.46) | ADRA2BADRA2CMEN1KMT2AEPHB3 | |
| SCHEMBL11187742 | 0.75 | CNR1 (0.49) | CYP1A2CYP2D6MAPTKDM4ETSHR | |
| SCHEMBL11187150 | 0.75 | CYP2D6 (0.37) | CYP1A2CYP2D6LMNATSHR | |
| Hydrochloric Acid SCHEMBL11191332 | 0.74 | CYP2D6 (0.36) | CYP1A2CYP2D6MAPTLMNATSHR | |
| SCHEMBL11182832 | 0.73 | KDM4E (0.52) | MEN1KMT2ACYP1A2MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL9654721 | 0.73 | PKM (0.37) | ADRA2BADRA2CMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL9654668 | 0.72 | POLB (0.40) | DHFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420619-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0004561-B1 | UREA AND AMIDE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICALS CONTAINING THEM AND THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS | CIBA-GEIGY AG (CH) | 1981-11-04 | — | — | EP | disclosed |
| US-4292429-A | Imidazole urea and amido compounds | CIBA-GEIGY CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |