Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11185372 | 0.89 | ACE (0.53) | ACEHTTGAAPOLBRAB9A | |
| SCHEMBL683282 | 0.84 | GAA (0.70) | ACEHTTGAAPOLBRAB9A | |
| SCHEMBL11102513 | 0.81 | ACE (0.68) | ACEHTTGAAPOLBRAB9A | |
| Rentiapril SCHEMBL294980 | 0.81 | ACE (1.00) | ACEHTTPOLBFFAR2ALDH1A1 | |
| Rentiapril SCHEMBL11065900 | 0.81 | ACE (1.00) | ACEHTTPOLBFFAR2ALDH1A1 | |
| Rentiapril SCHEMBL323403 | 0.81 | ACE (1.00) | ACEHTTPOLBFFAR2ALDH1A1 | |
| SCHEMBL11059109 | 0.77 | ACE (0.65) | ACEGAAPOLBRAB9AFFAR2 | |
| SCHEMBL683637 | 0.76 | ACE (0.67) | ACEGAAPOLBRAB9AFFAR2 | |
| SCHEMBL11062771 | 0.76 | ACE (0.67) | ACEGAAPOLBRAB9AFFAR2 | |
| SCHEMBL11062272 | 0.76 | ACE (0.66) | ACEGAAPOLBRAB9AFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |