Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11186352 | 0.87 | POLB (0.40) | ACEPOLBGAARAB9AALDH1A1 | |
| SCHEMBL11257867 | 0.84 | HSD17B10 (0.45) | ACEPOLBGAARAB9AALDH1A1 | |
| SCHEMBL11190627 | 0.83 | POLB (0.42) | ACEPOLBGAARAB9AALDH1A1 | |
| SCHEMBL11198907 | 0.83 | POLB (0.39) | ACEPOLBGAARAB9AALDH1A1 | |
| SCHEMBL11183354 | 0.81 | GAA (0.59) | POLBGAARAB9AALDH1A1MAPT | |
| SCHEMBL10969787 | 0.80 | ACE (0.57) | ACEPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL11189466 | 0.76 | GAA (0.37) | POLBGAARAB9AALDH1A1MAPT | |
| SCHEMBL11219640 | 0.75 | ACE (0.36) | ACEPOLBGAAALDH1A1HPGD | |
| SCHEMBL11190294 | 0.74 | ACE (0.50) | ACEPOLBGAARAB9AHSD17B10 | |
| SCHEMBL11192578 | 0.74 | LMNA (0.53) | ACEPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |