Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11190858 | 1.00 | KMT2A (0.55) | KMT2ALMNATSHRDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL11185849 | 0.85 | BLM (0.42) | KMT2ALMNATSHRDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL11185854 | 0.85 | BLM (0.42) | KMT2ALMNATSHRDRD2DRD1 | |
| SCHEMBL11076235 | 0.80 | DRD2 (0.35) | KMT2ALMNATSHRDRD2DRD1 | |
| SCHEMBL15894867 | 0.80 | DRD2 (0.35) | KMT2ALMNATSHRDRD2DRD1 | |
| SCHEMBL11076232 | 0.80 | DRD2 (0.35) | KMT2ALMNATSHRDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL11073001 | 0.80 | POLB (0.36) | KMT2ALMNATSHRDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL11184788 | 0.80 | POLB (0.36) | KMT2ALMNATSHRDRD2DRD1 | |
| SCHEMBL15894895 | 0.77 | DRD3 (0.58) | KMT2ALMNATSHRDRD2DRD3 | |
| SCHEMBL11189082 | 0.75 | LMNA (0.41) | KMT2ALMNATSHRDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| EP-0050881-A1 | Octahydro quinoline derivatives | ELI LILLY AND COMPANY (US) | 1982-05-05 | — | — | EP | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0013787-A1 | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |