Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11198380 | 0.84 | LMNA (0.47) | TDP1LMNAPOLBALDH1A1MAOB | |
| SCHEMBL11276410 | 0.83 | ALDH1A1 (0.52) | TDP1LMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11197653 | 0.82 | LMNA (0.49) | TDP1LMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL7745926 | 0.77 | TDP1 (0.51) | TDP1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7746533 | 0.76 | TDP1 (0.56) | TDP1LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7056985 | 0.76 | LMNA (0.69) | TDP1LMNAPOLBALDH1A1MAOB | |
| SCHEMBL23915480 | 0.75 | LMNA (0.58) | TDP1LMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL335272 | 0.75 | TDP1 (0.70) | TDP1LMNAPOLBALDH1A1CYP1A2 | |
| SCHEMBL23914948 | 0.75 | KMT2A (0.60) | TDP1LMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL11143151 | 0.74 | LMNA (0.56) | TDP1LMNAPOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4381304-A | 4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives | AYERST, MCKENNA & HARRISON, INC. (CA) | 1983-04-26 | — | — | US | disclosed |