Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119719 | 0.94 | TRPM8 (0.37) | TRPM8HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL1119726 | 0.88 | TRPM8 (0.41) | TRPM8HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL1120015 | 0.83 | RAB9A (0.38) | TRPM8MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL1120014 | 0.83 | RAB9A (0.38) | TRPM8MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL1120046 | 0.82 | TRPM8 (0.40) | TRPM8HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL1119717 | 0.78 | EGFR (0.37) | TRPM8MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL1119718 | 0.78 | EGFR (0.37) | TRPM8MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL3226499 | 0.77 | TRPM8 (0.36) | TRPM8HTR2AKMT2ANR1H4PPARG | |
| SCHEMBL1119874 | 0.77 | TRPM8 (0.44) | TRPM8MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL3230458 | 0.77 | BCL9 (0.38) | TRPM8MEN1LMNAKMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999000-B2 | N-(2-amino-phenyl)-acrylamides | HOFFMANN-LA ROCHE INC. (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2280940-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009138338-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-19 | — | — | WO | disclosed |
| US-20090286848-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | HOFFMANN-LA ROCHE INC. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286848-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | MKI67, CCNA2, CCNA1 | TRPM8 4248/4885HTR2A 1110/4885HTR2C 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.