Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196684 | 0.83 | SLC6A2 (0.42) | PRMT5WDR77HAO1KMT2ABACE1 | |
| SCHEMBL11194858 | 0.83 | S1PR4 (0.39) | S1PR1S1PR5PRMT5WDR77HAO1 | |
| SCHEMBL11198885 | 0.82 | SLC6A2 (0.41) | PRMT5WDR77HAO1KDM4EGLA | |
| SCHEMBL11195005 | 0.75 | NOTUM (0.45) | S1PR1S1PR5S1PR3HAO1KDM4E | |
| SCHEMBL10308947 | 0.75 | ALPL (0.41) | HAO1KDM4EGLAKMT2ASMN1; SMN2 | |
| SCHEMBL11203285 | 0.74 | S1PR1 (0.44) | S1PR1S1PR5S1PR3HAO1KDM4E | |
| SCHEMBL11201412 | 0.74 | S1PR1 (0.44) | S1PR1S1PR5S1PR3HAO1KDM4E | |
| SCHEMBL482476 | 0.72 | GPR35 (0.35) | KDM4ESMN1; SMN2 | |
| SCHEMBL30633578 | 0.72 | GPR35 (0.35) | KDM4ESMN1; SMN2 | |
| SCHEMBL28257105 | 0.72 | DHODH (0.43) | S1PR1S1PR5DHODHDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4381306-A | Hydroxypropyl-triazole compounds, their production and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1983-04-26 | — | — | US | disclosed |