Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11337882 | 0.83 | ALDH1A1 (0.62) | HRH2HRH1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL9242962 | 0.83 | ALDH1A1 (0.62) | HRH2HRH1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL12156753 | 0.82 | HRH2 (0.49) | CYP2D6HRH2HRH1ALDH1A1HTT | |
| SCHEMBL20097555 | 0.82 | USP2 (0.45) | CYP2D6HRH2HRH1ALDH1A1POLB | |
| SCHEMBL10534519 | 0.82 | HSD11B1 (0.45) | CYP2D6HRH2HRH1ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL10760926 | 0.81 | ALDH1A1 (0.61) | HRH2HRH1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14242965 | 0.81 | ALOX15 (0.50) | CYP2D6HRH2HRH1ALDH1A1HTT | |
| SCHEMBL771744 | 0.81 | HRH2 (0.45) | CYP2D6HRH2HRH1ALDH1A1HTT | |
| SCHEMBL39755 | 0.80 | USP2 (0.50) | ALDH1A1SMN1; SMN2HTTPOLBMAPT | |
| SCHEMBL12846943 | 0.79 | HRH2 (0.56) | CYP2D6HRH2HRH1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004163-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004163-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | OPRD1, OPRM1, OPRK1 | CYP2D6 427/4885HRH2 361/4885HRH1 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.