Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11193326 | 0.89 | CYP2A13 (0.75) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL11199250 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL4327006 | 0.80 | MPO (0.75) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL4108619 | 0.80 | CYP2A13 (0.69) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL111727 | 0.80 | CYP2A13 (0.64) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL2251851 | 0.80 | CYP2A13 (0.64) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL22711364 | 0.80 | CYP2A13 (0.64) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL3738488 | 0.80 | CYP2A13 (0.69) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL3730392 | 0.79 | CYP2A13 (0.67) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 | |
| SCHEMBL10787841 | 0.79 | MPO (0.72) | CYP2A13ALDH1A1CYP2C9KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333932-A | DIHYDROISOINDOLES, HYPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1982-06-08 | — | — | US | claimed |
| EP-0010896-A1 | Organic diamine compounds for use as oral hypoglycemic agents and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-05-14 | — | — | EP | claimed |
| US-4414220-A | HUPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4414220-A | HUPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4333932-A | DIHYDROISOINDOLES, HYPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4333932-A | DIHYDROISOINDOLES, HYPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4220650-A | HYPOGLYCEMIC | PFIZER INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4220650-A | HYPOGLYCEMIC | PFIZER INC. (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0010896-A1 | Organic diamine compounds for use as oral hypoglycemic agents and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-05-14 | — | — | EP | disclosed |