Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245979 | 0.77 | ADORA2A (0.51) | KDM4EALDH1A1CYP1A2LMNARAD52 | |
| SCHEMBL27474146 | 0.77 | LMNA (0.47) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8284883 | 0.77 | LMNA (0.47) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11710442 | 0.76 | MAPT (0.69) | KDM4EALDH1A1AGTR1GAAMAPT | |
| SCHEMBL11156129 | 0.75 | MAPT (0.61) | KDM4EALDH1A1AGTR1GAAMAPT | |
| SCHEMBL11219383 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11261496 | 0.74 | LMNA (0.44) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL119513 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL6466332 | 0.72 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23577963 | 0.72 | EGFR (0.45) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034529-B1 | TRIAZOLOQUINAZOLINONE DERIVATIVES AND THEIR ACID ADDITION SALTS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1983-07-20 | — | — | EP | disclosed |
| US-4350695-A | Antihistaminic and bronchospasmolytic triazoloquinazolinones | ROUSSEL UCLAF (FR) | 1982-09-21 | — | — | US | disclosed |
| EP-0034529-A1 | Triazoloquinazolinone derivatives and their acid addition salts, their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-08-26 | — | — | EP | disclosed |