Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457397 | 0.87 | ACHE (0.50) | ACHETDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL424538 | 0.87 | IDO1 (0.46) | ACHESMN1; SMN2ALDH1A1LMNAIDO1 | |
| SCHEMBL20868149 | 0.80 | ACHE (0.68) | ACHENFE2L2TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7025938 | 0.79 | — | — | |
| SCHEMBL12689 | 0.79 | — | — | |
| SCHEMBL6485306 | 0.78 | TSHR (0.48) | NFE2L2SMN1; SMN2ALDH1A1LMNAIDO1 | |
| SCHEMBL2680435 | 0.78 | ACHE (0.65) | ACHENFE2L2TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10799692 | 0.78 | TSHR (0.48) | ACHETDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10639836 | 0.78 | TSHR (0.48) | TDP1SMN1; SMN2ALDH1A1LMNAIDO1 | |
| SCHEMBL21831189 | 0.76 | ACHE (0.62) | ACHENFE2L2TDP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |