Sugi Predict

Sugi Predict / Compounds / SCHEMBL424538

SCHEMBL424538

SCHEMBL424538

Fc1ccc(C(Cl)c2ccc(F)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 3/20 0.46
▸ TDO2 P48775 2/20 0.46
▸ HDAC3 O15379 1/20 0.39
▸ HDAC4 P56524 1/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC7 Q8WUI4 1/20 0.39
▸ HDAC2 Q92769 1/20 0.39
▸ HDAC10 Q969S8 1/20 0.39
▸ HDAC11 Q96DB2 1/20 0.39
▸ HDAC8 Q9BY41 1/20 0.39
▸ HDAC6 Q9UBN7 1/20 0.39
▸ HDAC9 Q9UKV0 1/20 0.39
▸ HDAC5 Q9UQL6 1/20 0.39
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA7 P43166 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ ACHE P22303 1/20 0.38
▸ AOC3 Q16853 1/20 0.35
▸ CYP19A1 P11511 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6485306 0.89 TSHR (0.48) IDO1TDO2CYP19A1ALDH1A1LMNA
SCHEMBL10639836 0.89 TSHR (0.48) IDO1TDO2CYP19A1ALDH1A1LMNA
SCHEMBL11201293 0.87 ACHE (0.62) IDO1TDO2ACHEALDH1A1LMNA
SCHEMBL30599784 0.85 CYP19A1 (0.45) CYP19A1
Hydrochloric Acid SCHEMBL11198409 0.83 CYP19A1 (0.43) IDO1TDO2CYP19A1
SCHEMBL6903910 0.81 TSHR (0.50) IDO1TDO2HDAC3HDAC4HDAC1
SCHEMBL29021074 0.79 IDO1 (0.44) IDO1TDO2HDAC3HDAC4HDAC1
SCHEMBL4045962 0.77 IDO1 (0.42) IDO1TDO2HDAC3HDAC4HDAC1
SCHEMBL16027483 0.77 IDO1 (0.42) IDO1TDO2HDAC3HDAC4HDAC1
SCHEMBL930683 0.77 IDO1 (0.42) IDO1TDO2HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118662583-A Composition for preventing and treating encephalatrophy and preparation method thereof 情志健康管理(上海)有限公司 2024-09-20 — — CN claimed
CN-109666008-A A kind of synthetic method of lomerizine hydrochloride 辰欣药业股份有限公司 2019-04-23 — — CN claimed
EP-1432668-A1 PRODUCTION OF 4-FLUOROBENZALDEHYDE ALBEMARLE CORPORATION (US) 2004-06-30 — — EP claimed
WO-2003022788-A1 PRODUCTION OF 4-FLUOROBENZALDEHYDE ALBEMARLE CORPORATION (US) 2003-03-20 — — WO claimed
US-6455739-B1 CARBONYLATION OF FLUOROBENZENE USING CARBON MONOXIDE IN THE PRESENCE OF HYDROGEN CHLORIDE AS A CATALYSTS AND LEWIS ACIDS TO FORM COMPLEX BY PRODUCTS, THEN QUENCHING BY SOLVOLYSIS ALBEMARLE CORPORATION 2002-09-24 — — US claimed
EP-0166302-A2 \"1-[Bis-(4-fluorophyl)methyl]-4-(3-phenyl-2-propenyl)-hexahydro-1H-1,4-diazepine, preparation thereof and compositions containing it POLI INDUSTRIA CHIMICA S.p.A. (IT) 1986-01-02 — — EP claimed
US-4123420-A Aromatic copolyester composition containing phosphorus compounds UNITIKA LTD. (JP) 1978-10-31 — — US claimed
US-12600722-B2 Tetracyclic compounds as DGK inhibitors INCYTE CORPORATION (US) 2026-04-14 — — US disclosed
US-12600723-B2 Tetracyclic compounds as DGK inhibitors INCYTE CORPORATION (US) 2026-04-14 — — US disclosed
US-20250186450-A1 COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS INCYTE CORPORATION 2025-06-12 — — US disclosed
WO-2025122695-A1 COMBINATION THERAPY COMPRISING DGK INHIBITORS AND PD-1/PD-L1 INHIBITORS INCYTE CORPORATION (US) 2025-06-12 — — WO disclosed
WO-2025122545-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION (US) 2025-06-12 — — WO disclosed
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION 2025-06-05 — — US disclosed
US-4521537-A ANALGESICS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1985-06-04 — — US disclosed
EP-0102034-A1 Spiro(2H-1,4-benzodioxepin-3(5H)4'-piperidine and 3'-pyrrolidino) compounds, a process for preparing the same and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1984-03-07 — — EP disclosed
US-4180670-A Amino pyridine derivatives JOHN WYETH & BROTHER LIMITED (GB) 1979-12-25 — — US disclosed
US-4118561-A ANTIBACTERIAL, SYNERGISTIC, ANTI-CANCER ACTIVITY, ANTI-FOLIC ACID ACTIVITY AMERICAN HOME PRODUCTS CORPORATION (US) 1978-10-03 — — US disclosed
US-4079137-A FOR TREATMENT OF VASCULAR AND CARDIAC DISEASES KNOLL A.G. CHEMISCHE FABRIKEN (DT) 1978-03-14 — — US disclosed
US-4017631-A MICROBIOCIDES JANSSEN PHARMACEUTICA N.V. (BE) 1977-04-12 — — US disclosed
US-3991202-A ANTIMICROBIALS JANSSEN PHARMACEUTICA N.V. (BE) 1976-11-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186450-A1 COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS DGKG, DCK, DGKA IDO1 2452/4885TDO2 4330/4885HDAC3 691/4885
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS DGKA, DGKI, DGKG IDO1 4255/4885TDO2 2353/4885HDAC3 468/4885
US-12600723-B2 Tetracyclic compounds as DGK inhibitors DGKB, DGKA, NR2C2 IDO1 4774/4885TDO2 2721/4885HDAC3 787/4885
US-12600722-B2 Tetracyclic compounds as DGK inhibitors DGKB, DGKA, DGKK IDO1 4786/4885TDO2 2652/4885HDAC3 884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.