SCHEMBL11201469

SCHEMBL11201469

ClCCCn1c(-c2ccccc2)nc2ccccc21

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.65
PDE6D O43924 1/20 0.65
ALDH2 P05091 1/20 0.65
ALDH3A1 P30838 1/20 0.65
HPGD P15428 1/20 0.62
KDM4E B2RXH2 4/20 0.59
TP53 P04637 5/20 0.58
HSD17B10 Q99714 3/20 0.57
P2RX7 Q99572 1/20 0.56
LMNA P02545 2/20 0.55
TSHR P16473 2/20 0.55
GAA P10253 2/20 0.54
DRD2 P14416 2/20 0.52
DRD3 P35462 2/20 0.52
PIN1 Q13526 2/20 0.52
MAPT P10636 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
JAK2 O60674 1/20 0.51
JAK1 P23458 1/20 0.51
TYK2 P29597 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3336044 0.95 ALDH1A1 (0.63) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL3336250 0.94 ALDH1A1 (0.61) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL3331202 0.85 ALDH1A1 (0.64) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL10323108 0.84 TLR7 (0.64) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL9321137 0.84 TP53 (0.72) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL3336215 0.84 ALDH1A1 (0.63) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL4938222 0.83 HPGD (0.61) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL4946603 0.82 HPGD (0.59) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL15314762 0.81 ALDH1A1 (0.73) ALDH1A1PDE6DALDH2ALDH3A1HPGD
SCHEMBL6387107 0.81 HPGD (0.66) ALDH1A1PDE6DALDH2ALDH3A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4377578-A ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES JANSSEN PHARMACEUTICA, N.V. (BE) 1983-03-22 US disclosed
US-4250176-A BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES JANSSEN PHARMACEUTICA N.V. (BE) 1981-02-10 US disclosed
US-4200641-A ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES JANSSEN PHARMACEUTICA, N.V. (BE) 1980-04-29 US disclosed