Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11203991 | 0.89 | HTR2A (0.38) | KHKHTR2AHRH1USP2SMN1; SMN2 | |
| SCHEMBL11205170 | 0.86 | ALDH1A1 (0.42) | KHKHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11203366 | 0.85 | KHK (0.41) | KHKHTR2AHRH1USP2SMN1; SMN2 | |
| SCHEMBL11202792 | 0.84 | KHK (0.38) | KHKHTR2AHRH1USP2SMN1; SMN2 | |
| SCHEMBL11202267 | 0.83 | KDM4E (0.39) | HTR2AHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11201110 | 0.83 | HRH4 (0.36) | HRH4KDM4EALDH1A1 | |
| SCHEMBL11197095 | 0.81 | CETP (0.39) | KHKHTR2AHRH1USP2SMN1; SMN2 | |
| SCHEMBL11200202 | 0.81 | KHK (0.38) | KHKHTR2AHRH1USP2SMN1; SMN2 | |
| SCHEMBL11201393 | 0.79 | HRH1 (0.41) | HRH1USP2SMN1; SMN2TDP1HRH4 | |
| SCHEMBL11197339 | 0.78 | HTR2C (0.39) | KHKHTR2AHRH1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0082023-A2 | Thienopyrimidine derivatives, their preparation and their medical use | SANKYO COMPANY LIMITED (JP) | 1983-06-22 | — | — | EP | disclosed |