Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | PGR | P06401 | 3/20 | 0.57 |
| ▸ | RGS4 | P49798 | 1/20 | 0.57 |
| ▸ | RGS8 | P57771 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471780 | 0.79 | HPGD (0.58) | MAPK8MAPK9MAPTPGRRGS4 | |
| SCHEMBL31743715 | 0.78 | CCR2 (0.60) | MAPK8MAPK9MAPTPGRTHRB | |
| SCHEMBL11141094 | 0.77 | FABP4 (0.49) | MAPK8MAPK9MAPTTHRBKDM4E | |
| SCHEMBL11135875 | 0.77 | FABP4 (0.49) | MAPK8MAPK9MAPTTHRBKDM4E | |
| SCHEMBL31743597 | 0.76 | CCR2 (0.54) | MAPK8MAPK9MAPTPGRTHRB | |
| SCHEMBL11138526 | 0.76 | FABP4 (0.48) | MAPK8MAPK9MAPTTHRBKDM4E | |
| SCHEMBL11135947 | 0.76 | FABP4 (0.48) | MAPK8MAPK9MAPTTHRBKDM4E | |
| SCHEMBL31743765 | 0.73 | MAPK8 (0.54) | MAPK8MAPK9MAPTPDE4APDE4B | |
| SCHEMBL4211726 | 0.73 | MAPK8 (0.61) | MAPK8MAPK9MAPTPGRRGS4 | |
| SCHEMBL5326569 | 0.73 | MAPK8 (0.53) | MAPK8MAPK9MAPTPGRRGS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |