Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9477815 | 0.84 | PDE3B (0.50) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11018929 | 0.77 | PDE3B (0.54) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL10853063 | 0.77 | PDE3B (0.51) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL9478348 | 0.76 | ALDH1A1 (0.49) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11025183 | 0.76 | PDE3B (0.50) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11025198 | 0.76 | PDE3B (0.50) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11022787 | 0.75 | PDE3B (0.46) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11021631 | 0.74 | KDM4E (0.43) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11020956 | 0.74 | KDM4E (0.43) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11022099 | 0.74 | PDE3B (0.52) | PDE3BPDE3AKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415580-A | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same | STERLING DRUG INC. (US) | 1983-11-15 | — | — | US | disclosed |