Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279975 | 0.78 | LMNA (0.34) | LMNA | |
| SCHEMBL18724677 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL28286022 | 0.74 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2APOLBNPC1 | |
| SCHEMBL20456222 | 0.74 | — | — | |
| SCHEMBL26660601 | 0.74 | — | — | |
| SCHEMBL1233273 | 0.74 | — | — | |
| SCHEMBL3663208 | 0.74 | — | — | |
| SCHEMBL4629370 | 0.73 | CHRM2 (0.33) | ALDH1A1LMNA | |
| SCHEMBL15659638 | 0.72 | — | — | |
| SCHEMBL1120453 | 0.72 | LMNA (0.45) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |