Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112286 | 0.78 | HTT (0.56) | HTTCRBNIKZF3L3MBTL1LMNA | |
| SCHEMBL3629080 | 0.76 | MRGPRX4 (0.62) | HTTCRBNIKZF3L3MBTL1LMNA | |
| SCHEMBL25835377 | 0.75 | MAOA (0.46) | HTTCRBNIKZF3L3MBTL1BRD4 | |
| SCHEMBL16072720 | 0.74 | KCNA3 (0.58) | HTTL3MBTL1BRD4MAPTMAPK1 | |
| SCHEMBL31297867 | 0.74 | ACHE (0.70) | LMNAMAPTPOLB | |
| SCHEMBL29414837 | 0.74 | MAPT (0.54) | L3MBTL1BRD4CREBBPMAPTMAPK1 | |
| SCHEMBL22632886 | 0.74 | MAPT (0.54) | L3MBTL1BRD4CREBBPMAPTMAPK1 | |
| SCHEMBL5101144 | 0.73 | MRGPRX4 (0.74) | HTTCRBNIKZF3L3MBTL1LMNA | |
| SCHEMBL31318410 | 0.73 | MRGPRX4 (0.74) | HTTCRBNIKZF3L3MBTL1LMNA | |
| SCHEMBL9173435 | 0.73 | KCNA3 (0.56) | HTTL3MBTL1BRD4MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080117-A2 | The (R,R)-enantiomer of trans-indeno(1,2-b)-1,4-oxazines, process for its preparation and pharmaceutical formulation containing it | MERCK & CO. INC. (US) | 1983-06-01 | — | — | EP | disclosed |