Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15547537 | 0.80 | CA12 (0.42) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2509039 | 0.78 | FFAR1 (0.48) | CA12CA1CA2CA3CA4 | |
| SCHEMBL1672797 | 0.78 | FFAR1 (0.48) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3087191 | 0.78 | FFAR1 (0.48) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11847778 | 0.76 | FFAR1 (0.46) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL6972010 | 0.76 | FFAR1 (0.52) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL4800015 | 0.75 | FFAR1 (0.46) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL20827294 | 0.75 | FFAR1 (0.41) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL7078392 | 0.75 | HPGD (0.39) | CA12CA1CA2CA3CA4 | |
| SCHEMBL3038672 | 0.74 | SIRT1 (0.47) | FFAR1HPGDMAPTHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021150-B1 | PAROMOMYCIN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTICAL COMPOSITION CONTAINING THEM | FARMITALIA CARLO ERBA S.p.A. (IT) | 1983-05-18 | — | — | EP | claimed |
| US-4337248-A | FOR TREATING AMOEBIC DYSENTERY | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-06-29 | — | — | US | claimed |
| EP-0021150-A1 | Paromomycin derivatives, a process for the preparation thereof and therapeutical composition containing them | FARMITALIA CARLO ERBA S.p.A. (IT) | 1981-01-07 | — | — | EP | claimed |