Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4316403 | 0.87 | GAA (0.57) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL7283471 | 0.82 | PDE3B (0.60) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL11198704 | 0.82 | NAMPT (0.67) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL27569658 | 0.82 | NAMPT (0.60) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL16276101 | 0.80 | LMNA (0.64) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL11194619 | 0.79 | SMN1; SMN2 (0.57) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL11194616 | 0.79 | SMN1; SMN2 (0.57) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL16134867 | 0.79 | POLB (0.70) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL11194908 | 0.79 | SMN1; SMN2 (0.60) | LMNAGAASMN1; SMN2HTTMAPT | |
| SCHEMBL9173237 | 0.78 | KMT2A (0.77) | LMNAGAASMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1142157-C | Thenoyl piperazine derivative with positive myodyamia effect | 上海众普生物科技有限公司 | 2004-03-17 | — | — | CN | disclosed |
| CN-1344715-A | Thenoyl piperazine derivative with positive myodyamia effect | SHANGHAI ZHONGPU BIOLOG SCIENC (CN) | 2002-04-17 | — | — | CN | disclosed |
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |