Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.66 |
| ▸ | DRD3 | P35462 | 3/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11231248 | 0.98 | DRD2 (0.64) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL11228330 | 0.90 | DRD2 (0.56) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL11205417 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL11243427 | 0.79 | DRD2 (0.97) | DRD2DRD3 | |
| SCHEMBL23043397 | 0.77 | PRKACA (0.54) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL16124191 | 0.77 | PRKACA (0.54) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL17485781 | 0.77 | PRKACA (0.54) | DRD2DRD3DAPK3JAK2CSF1R | |
| Maleic Acid SCHEMBL11206829 | 0.75 | DRD2 (0.41) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL4181234 | 0.73 | PRKACA (0.54) | DRD2DRD3DAPK3JAK2CSF1R | |
| SCHEMBL16123977 | 0.73 | PRKACA (0.54) | DRD2DRD3DAPK3JAK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013789-B1 | AMINO-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H (OR 2H)-INDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1983-02-02 | — | — | EP | disclosed |
| US-4322540-A | PROLACTIN INHIBITOR | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| US-4322430-A | Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| US-4276300-A | PROLACTIN INHIBITORS | ELI LILLY AND COMPANY (US) | 1981-06-30 | — | — | US | disclosed |
| EP-0013789-A1 | Amino-substituted 4,5,6,7-tetrahydro-1H (or 2H)-indazoles, their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |