Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | GRK5 | P34947 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19768751 | 0.85 | DRD2 (0.43) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL28275958 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL15014504 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL16123977 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL2207712 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL4181234 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL28274578 | 0.77 | PRKACA (0.54) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL11206333 | 0.77 | DRD2 (0.66) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL16228059 | 0.75 | PRKACA (0.53) | PRKACAKDRCDK8CDK9ROCK1 | |
| SCHEMBL16118860 | 0.75 | PRKACA (0.53) | PRKACAKDRCDK8CDK9ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4182313-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-05-24 | — | — | EP | disclosed |
| EP-4021444-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2022015375-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-01-20 | — | — | WO | disclosed |
| WO-2021041671-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-03-04 | — | — | WO | disclosed |