Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30832967 | 1.00 | HDAC1 (0.60) | HDAC1HDAC2HDAC3KMT2ATDP1 | |
| SCHEMBL15551319 | 0.86 | HDAC2 (0.51) | HDAC1HDAC2HDAC3KMT2ATDP1 | |
| SCHEMBL14155797 | 0.86 | HDAC2 (0.77) | HDAC1HDAC2HDAC3TDP1NPC1 | |
| SCHEMBL9509772 | 0.85 | NPC1 (0.55) | HDAC1HDAC2HDAC3KMT2ATDP1 | |
| SCHEMBL8110762 | 0.82 | HDAC2 (0.83) | HDAC1HDAC2HDAC3NPC1RAB9A | |
| SCHEMBL1708819 | 0.82 | HDAC1 (0.62) | HDAC1HDAC2HDAC3KMT2ATDP1 | |
| SCHEMBL11646949 | 0.82 | HDAC1 (0.50) | HDAC1HDAC2HDAC3KMT2ATDP1 | |
| SCHEMBL11640192 | 0.82 | HDAC1 (0.50) | HDAC1HDAC2HDAC3TDP1HPGD | |
| SCHEMBL10372226 | 0.81 | HDAC1 (0.60) | HDAC1HDAC2HDAC3HPGDALDH1A1 | |
| SCHEMBL11512570 | 0.81 | HDAC1 (0.60) | HDAC1HDAC2HDAC3KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981665-B2 | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof | CHEN ZHIHONG (US) | 2024-05-14 | — | — | US | disclosed |
| CN-111683662-B | Substituted pyrimidine compounds, pharmaceutical compositions and methods of treatment | 陈志宏 | 2024-04-02 | — | — | CN | disclosed |
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-20230109688-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | CHEN ZHIHONG (US) | 2023-04-13 | — | — | US | disclosed |
| EP-3675860-B1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | ZHIHONG CHEN (US) | 2023-03-08 | — | — | EP | disclosed |
| US-20230056253-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. | 2023-02-23 | — | — | US | disclosed |
| US-11440904-B2 | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof | CHEN ZHIHONG (US) | 2022-09-13 | — | — | US | disclosed |
| US-20210161144-A1 | MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2021-06-03 | — | — | US | disclosed |
| CN-111683662-A | Substituted pyrimidines, pharmaceutical compositions and methods of treatment | 陈志宏 | 2020-09-18 | — | — | CN | disclosed |
| EP-3675860-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | Zhihong, Chen (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20200190068-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | CHEN ZHIHONG (US) | 2020-06-18 | — | — | US | disclosed |
| WO-2019046163-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | ZHIHONG CHEN (US) | 2019-03-07 | — | — | WO | disclosed |
| US-8431538-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120252740-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME | KOZIKOWSKI ALAN (US) | 2012-10-04 | — | — | US | disclosed |
| EP-0038453-B1 | PROCESS FOR THE PREPARATION OF WATER SOLUBLE PHTHALOCYANINE DYESTUFFS | BAYER AG (DE) | 1983-05-25 | — | — | EP | disclosed |
| EP-0038453-A2 | Process for the preparation of water soluble phthalocyanine dyestuffs | BAYER AG (DE) | 1981-10-28 | — | — | EP | disclosed |
| US-4062838-A | LACQUERS, PRINTING INKS, YELLOW TO ORANGE | CIBA-GEIGY CORPORATION (US) | 1977-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252740-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME | HDAC1, HDAC9, HDAC5 | HDAC1 1/4885HDAC2 4/4885HDAC3 10/4885 |
| US-20200190068-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | BTK, PTK2, LCK | HDAC1 2735/4885HDAC2 1615/4885HDAC3 2190/4885 |
| US-20230056253-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | TP53, TP53BP1, HRAS | HDAC1 1151/4885HDAC2 2703/4885HDAC3 2139/4885 |
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | HDAC1 1151/4885HDAC2 2703/4885HDAC3 2139/4885 |
| US-20210161144-A1 | MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO | ACHE, DDT, MLYCD | HDAC1 3044/4885HDAC2 2568/4885HDAC3 3070/4885 |
| US-20230109688-A1 | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF | BTK, PTK2, LCK | HDAC1 2735/4885HDAC2 1615/4885HDAC3 2190/4885 |
| US-11981665-B2 | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof | BTK, PTK2, LCK | HDAC1 2735/4885HDAC2 1615/4885HDAC3 2190/4885 |
| US-11440904-B2 | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof | BTK, PTK2, LCK | HDAC1 2735/4885HDAC2 1615/4885HDAC3 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.