Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2138571 | 1.00 | CYP2C19 (0.56) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| SCHEMBL161069 | 0.91 | CYP2C19 (0.50) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL28294820 | 0.88 | CYP2C19 (0.48) | CYP2C19HIF1ACYP1A2CYP2D6KCNN4 | |
| SCHEMBL8164004 | 0.88 | CYP2C19 (0.48) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| Methoxymethane SCHEMBL10658658 | 0.80 | KCNN4 (0.48) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| Bicarbonate SCHEMBL27636738 | 0.79 | CYP1A2 (0.52) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| SCHEMBL72162 | 0.78 | CYP2C9 (0.52) | CYP2C19HIF1ACYP1A2MAPTKMT2A | |
| SCHEMBL9636971 | 0.78 | CYP2C9 (0.58) | CYP2C19HIF1ACYP1A2CYP2C9PTPN1 | |
| Bicarbonate SCHEMBL11436129 | 0.78 | MAPT (0.54) | CYP2C19HIF1ACYP1A2CYP2D6MAPT | |
| SCHEMBL7782322 | 0.77 | CYP2C19 (0.44) | CYP2C19HIF1ACYP1A2CYP2D6KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0026820-B1 | METHOD OF PRODUCING RELIEF STRUCTURES RESISTANT TO A HIGH TEMPERATURE, RELIEF STRUCTURES PRODUCED THEREBY AND THEIR USE | SIEMENS AKTIENGESELLSCHAFT (DE) | 1983-05-11 | — | — | EP | claimed |
| EP-0026820-A1 | Method of producing relief structures resistant to a high temperature, relief structures produced thereby and their use | SIEMENS AKTIENGESELLSCHAFT (DE) | 1981-04-15 | — | — | EP | claimed |
| EP-0026820-B1 | METHOD OF PRODUCING RELIEF STRUCTURES RESISTANT TO A HIGH TEMPERATURE, RELIEF STRUCTURES PRODUCED THEREBY AND THEIR USE | SIEMENS AKTIENGESELLSCHAFT (DE) | 1983-05-11 | — | — | EP | disclosed |
| EP-0026820-A1 | Method of producing relief structures resistant to a high temperature, relief structures produced thereby and their use | SIEMENS AKTIENGESELLSCHAFT (DE) | 1981-04-15 | — | — | EP | disclosed |