Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11137810 | 0.87 | PLK1 (0.62) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL22040686 | 0.86 | HDAC1 (0.61) | HDAC1HDAC6HDAC3NCOR2HDAC8 | |
| SCHEMBL5832015 | 0.81 | EPHX2 (0.47) | — | |
| SCHEMBL11120189 | 0.81 | ALDH1A1 (0.52) | — | |
| SCHEMBL10965456 | 0.80 | LOXL2 (0.59) | — | |
| SCHEMBL11125011 | 0.79 | S1PR1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL11189806 | 0.79 | ALDH1A1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL6364657 | 0.79 | LOXL2 (0.57) | — | |
| SCHEMBL5830605 | 0.78 | HTT (0.54) | HDAC1HDAC6HDAC8 | |
| SCHEMBL21058265 | 0.78 | SLC6A2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028105-B1 | SECONDARY AMINES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1983-01-19 | — | — | EP | disclosed |