SCHEMBL11207386

SCHEMBL11207386

NS(=O)(=O)c1ccc(Oc2ccccc2)c([N+](=O)[O-])c1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
TTR P02766 1/20 0.52
ALB P02768 1/20 0.52
THRB P10828 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CYP1A2 P05177 3/20 0.46
CYP2C19 P33261 2/20 0.46
CYP2D6 P10635 2/20 0.46
ALDH1A1 P00352 1/20 0.46
EPAS1 Q99814 2/20 0.45
SOS1 Q07889 1/20 0.43
P2RX4 Q99571 2/20 0.40
VEGFA P15692 1/20 0.39
CYP2C9 P11712 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP3A4 P08684 2/20 0.39
HTR2C P28335 2/20 0.39
SLC6A3 Q01959 2/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11206306 0.88 MEN1 (0.50) MEN1KMT2ATTRALBTHRB
SCHEMBL11047126 0.80 TDP1 (0.56) MEN1KMT2ATTRALBTHRB
SCHEMBL10482222 0.72 TLR8 (0.60) MEN1KMT2ATTRALBTHRB
SCHEMBL11033566 0.72 MEN1 (0.54) MEN1KMT2ATTRALBTHRB
SCHEMBL15067835 0.70 TDP1 (0.55) MEN1KMT2ATTRALBTHRB
SCHEMBL28301208 0.70 TDP1 (0.56) MEN1KMT2ATTRALBTHRB
SCHEMBL29449333 0.70 NPY1R (0.41) KMT2ACYP1A2CYP2C19ALDH1A1CYP2C9
SCHEMBL20787696 0.70 MAPT (0.47) MEN1KMT2ATTRALBTHRB
SCHEMBL4363285 0.70 MEN1 (0.59) MEN1KMT2ATTRALBTHRB
SCHEMBL11283981 0.70 TDP1 (0.51) MEN1KMT2ATTRALBTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-58124758-A None JP disclosed
JP-S58124758-A BENZENESULFONAMIDE DERIVATIVE FUJISAWA PHARMACEUT CO LTD 1983-07-25 JP disclosed