Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11424878 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HDAC1KDM4CPTGS1 | |
| SCHEMBL11440921 | 0.89 | ALDH1A1 (0.48) | KDM4EALDH1A1HDAC1KDM4CPTGS1 | |
| SCHEMBL11435352 | 0.88 | CASP6 (0.55) | HDAC1SMN1; SMN2CASP6CTDSP1MPL | |
| Acetic Acid SCHEMBL11426048 | 0.86 | ALDH1A1 (0.48) | KDM4EALDH1A1HDAC1KDM4CPTGS1 | |
| SCHEMBL10908295 | 0.84 | KMT2A (0.45) | ALDH1A1HSD17B10MPLMEN1MAPT | |
| SCHEMBL11433973 | 0.84 | ALDH1A1 (0.48) | KDM4EALDH1A1HDAC1KDM4CPTGS1 | |
| SCHEMBL11438930 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1HDAC1KDM4CPTGS1 | |
| SCHEMBL11339069 | 0.84 | KMT2A (0.53) | ALDH1A1HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL11438820 | 0.82 | CASP6 (0.40) | SMN1; SMN2CASP6CTDSP1MPLMEN1 | |
| SCHEMBL11433569 | 0.82 | MAPT (0.40) | CASP6CTDSP1MPLMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013784-B1 | C-SUBSTITUTED NAPHTHALENEMONOSULFONIC UREIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN CYANAMID COMPANY (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |