Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11604322 | 0.96 | AKR1B1 (0.57) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11604179 | 0.93 | MAPT (0.51) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10842353 | 0.90 | ALDH1A1 (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11604185 | 0.89 | AKR1B1 (0.55) | AKR1B1MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10843503 | 0.88 | ALDH1A1 (0.61) | MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11617961 | 0.88 | ALDH1A1 (0.56) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11085181 | 0.87 | ALDH1A1 (0.57) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11617346 | 0.87 | ALDH1A1 (0.52) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11603832 | 0.86 | AKR1B1 (0.59) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4008419 | 0.85 | ALDH1A1 (0.60) | AKR1B1MAPTALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0082521-A1 | 6,11-Dihydro-11,-oxo-dibenz(b,e)-oxepin derivatives, methods for their preparation, pharmaceutical compositions containing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-29 | — | — | EP | disclosed |