Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11206365 | 0.99 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRALDH1A1IGF1RALOX15 | |
| SCHEMBL11206369 | 0.97 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHRALDH1A1IGF1RALOX15 | |
| SCHEMBL11208706 | 0.86 | MAPT (0.48) | ALDH1A1HDAC6MAPK1MAPTLMNA | |
| SCHEMBL7359104 | 0.86 | MAPT (0.48) | ALDH1A1HDAC6MAPK1MAPTLMNA | |
| SCHEMBL11210382 | 0.85 | TSHR (0.44) | SMN1; SMN2TSHRIGF1RALOX15HDAC6 | |
| SCHEMBL11202315 | 0.83 | MAPT (0.45) | SMN1; SMN2ALDH1A1HDAC6MAPK1MAPT | |
| SCHEMBL7481816 | 0.83 | LMNA (0.51) | SMN1; SMN2ALDH1A1KDM4EHDAC6L3MBTL1 | |
| SCHEMBL11018171 | 0.82 | MAPT (0.47) | TSHRALDH1A1HDAC6MAPK1MAPT | |
| SCHEMBL6260245 | 0.82 | LMNA (0.53) | SMN1; SMN2ALDH1A1KDM4EHDAC6MAPK1 | |
| SCHEMBL7433424 | 0.82 | LMNA (0.53) | SMN1; SMN2ALDH1A1KDM4EHDAC6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025192-B1 | SUBSTITUTED OXIRANE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-05-11 | — | — | EP | disclosed |
| EP-0025192-A2 | Substituted oxirane carboxylic acids, process for their preparation, their use and medicines containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-03-18 | — | — | EP | disclosed |