⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014218 | 0.75 | — | — | |
| SCHEMBL6286076 | 0.75 | — | — | |
| SCHEMBL17414840 | 0.70 | CYP3A4 (0.39) | — | |
| SCHEMBL19747825 | 0.70 | — | — | |
| SCHEMBL2838749 | 0.70 | — | — | |
| SCHEMBL5646332 | 0.70 | — | — | |
| Water SCHEMBL15153794 | 0.69 | ALDH1A1 (0.50) | — | |
| SCHEMBL6769773 | 0.67 | — | — | |
| SCHEMBL26132618 | 0.67 | NPC1 (0.41) | — | |
| SCHEMBL54675 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3893645-A1 | SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2021-10-20 | — | — | EP | claimed |
| WO-2020123674-A1 | SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-06-18 | — | — | WO | claimed |
| CN-110818598-A | Cathepsin inhibitor and preparation method and application thereof | 沈阳药科大学 | 2020-02-21 | — | — | CN | claimed |
| CN-105441065-B | Detect fluorescence probe of hypochlorite ion and preparation method thereof and application method | 浙江理工大学 | 2018-05-25 | — | — | CN | claimed |
| CN-108250107-B | Cathepsin inhibitor and preparation method and application thereof | 沈阳药科大学 | 2021-04-09 | — | — | CN | disclosed |
| CN-105441065-B | Detect fluorescence probe of hypochlorite ion and preparation method thereof and application method | 浙江理工大学 | 2018-05-25 | — | — | CN | disclosed |
| EP-0016726-B1 | BASIC OR QUATERNISED AZODYESTUFFS OF THE 2-(4'-AZOPHENYL) BENZOTHIAZOLE SERIES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN DYEING AND PRINTING TEXTILE MATERIAL, PAPER AND LEATHER | CIBA-GEIGY AG (CH) | 1983-05-18 | — | — | EP | disclosed |
| EP-0016726-A3 | BASIC OR QUATERNISED AZODYESTUFFS OF THE 2-(4'-AZOPHENYL) BENZOTHIAZOLE SERIES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN DYEING AND PRINTING TEXTILE MATERIAL, PAPER AND LEATHER | — | 1980-10-15 | — | — | EP | disclosed |