Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 3/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.53 |
| ▸ | SHBG | P04278 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11242848 | 0.95 | ESR1 (0.52) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL11213690 | 0.91 | ESR1 (0.69) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL10327999 | 0.90 | ESR1 (0.67) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL11207655 | 0.88 | MAPT (0.66) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL11216046 | 0.87 | LMNA (0.67) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL11214603 | 0.87 | LMNA (0.67) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL11219023 | 0.87 | LMNA (0.67) | ESR1LMNASMN1; SMN2ATMPGR | |
| SCHEMBL10360572 | 0.86 | ESR1 (0.58) | ESR1LMNASMN1; SMN2ATMPGR | |
| Maleic Acid SCHEMBL11229073 | 0.86 | ESR1 (0.63) | ESR1LMNASMN1; SMN2ATMPGR | |
| Hydrochloric Acid SCHEMBL11247183 | 0.86 | LMNA (0.66) | ESR1LMNASMN1; SMN2ATMPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033561-B1 | NOVEL 17-AMINO-16-HYDROXY STEROIDS OF THE ANDROSTANE AND OESTRANE SERIES AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1983-05-11 | — | — | EP | disclosed |
| US-4330539-A | Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof | AKZO NV (NL) | 1982-05-18 | — | — | US | disclosed |
| EP-0033561-A1 | Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1981-08-12 | — | — | EP | disclosed |