Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 11/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15976590 | 0.88 | BCHE (0.43) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL2537519 | 0.80 | BCHE (0.42) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL29605929 | 0.79 | SMN1; SMN2 (0.42) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL3902887 | 0.78 | CYP2D6 (0.38) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL197080 | 0.78 | — | — | |
| SCHEMBL21545609 | 0.78 | GLI1 (0.41) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL23581827 | 0.78 | POLB (0.42) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL23592771 | 0.78 | CYP2D6 (0.36) | CYP2D6BCHECYP46A1DPP4SMN1; SMN2 | |
| SCHEMBL12436051 | 0.77 | KDM4E (0.43) | DPP4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL9381703 | 0.76 | GAA (0.46) | BCHEDPP4SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555063-B1 | 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2020-09-16 | — | — | EP | disclosed |
| WO-2018108704-A1 | NEW 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-21 | — | — | WO | disclosed |
| EP-2057156-B1 | 2-METHYLMORPHOLINE PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | KUDOS PHARM LTD (GB) | 2017-02-01 | — | — | EP | disclosed |
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |
| EP-0042570-B1 | 20-DEOXYROSARAMICIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1983-10-19 | — | — | EP | disclosed |
| EP-0042570-A1 | 20-Deoxyrosaramicin derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4279896-A | Novel 20-imino macrolide antibacterial agents | SCHERING CORPORATION (US) | 1981-07-21 | — | — | US | disclosed |