Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 10/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2537519 | 0.80 | BCHE (0.42) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL11209804 | 0.78 | CYP2D6 (0.38) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL21545609 | 0.78 | GLI1 (0.41) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL197080 | 0.78 | — | — | |
| SCHEMBL12436051 | 0.77 | KDM4E (0.43) | DPP4MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL15976590 | 0.75 | BCHE (0.43) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL4550355 | 0.75 | SMN1; SMN2 (0.60) | CYP2D6BCHEMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12026413 | 0.75 | MEN1 (0.42) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL1712529 | 0.75 | CYP2D6 (0.40) | CYP2D6BCHECYP46A1DPP4MEN1 | |
| SCHEMBL10205100 | 0.75 | CYP2D6 (0.37) | CYP2D6BCHECYP46A1DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |