Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
| ▸ | PTAFR | P25105 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11208277 | 0.88 | ALPG (0.74) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11203945 | 0.88 | ALPG (0.54) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL10767837 | 0.86 | AKR1B1 (0.55) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11216490 | 0.84 | ALPG (0.54) | ALPGTBXAS1PTAFR | |
| SCHEMBL28659590 | 0.82 | SMN1; SMN2 (0.51) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11009173 | 0.81 | ALPG (0.71) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11002512 | 0.79 | ALPG (0.58) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11175621 | 0.78 | ALPG (0.46) | ALPGSMN1; SMN2ALDH1A1KDM4ECASP1 | |
| SCHEMBL13923498 | 0.78 | ALPG (0.71) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11087151 | 0.78 | SMN1; SMN2 (0.47) | ALPGTBXAS1PTAFRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094080-A2 | Pyrido(2,1-b)quinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-11-16 | — | — | EP | disclosed |