Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9110973 | 0.89 | TSHR (0.62) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL14024617 | 0.84 | SIGMAR1 (0.54) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL3874218 | 0.82 | SIGMAR1 (0.53) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL666712 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 | |
| Hydrochloric Acid SCHEMBL31687522 | 0.81 | SIGMAR1 (0.51) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL23308021 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 | |
| SCHEMBL11258123 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 | |
| SCHEMBL667263 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 | |
| SCHEMBL667946 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 | |
| SCHEMBL667520 | 0.81 | SIGMAR1 (0.51) | KCNH2CYP2D6DRD2OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4021557-A | BRONCHOSPASMOLYTICS | BOEHRINGER INGELHEIM GMBH (DT) | 1977-05-03 | — | — | US | disclosed |