Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.62 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211249 | 0.89 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL3635237 | 0.83 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL9114952 | 0.83 | ALDH1A1 (0.49) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL170943 | 0.82 | BCHE (0.51) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL9111670 | 0.81 | KMT2A (0.50) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL13995625 | 0.81 | SIGMAR1 (0.47) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL13673936 | 0.81 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL4372177 | 0.81 | CARM1 (0.58) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL7982573 | 0.79 | ALDH1A1 (0.53) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C | |
| SCHEMBL14024617 | 0.79 | SIGMAR1 (0.54) | TSHRALDH1A1SMN1; SMN2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432284-A | Process for the preparation of heterocyclic alkylamide derivatives | G. D. SEARLE & CO. (US) | 1995-07-11 | — | — | US | claimed |
| WO-1995007273-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC ALKYLAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1995-03-16 | — | — | WO | claimed |
| US-5432284-A | Process for the preparation of heterocyclic alkylamide derivatives | G. D. SEARLE & CO. (US) | 1995-07-11 | — | — | US | disclosed |
| WO-1995007273-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC ALKYLAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1995-03-16 | — | — | WO | disclosed |
| US-5097035-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-17 | — | — | US | disclosed |
| US-4780477-A | Isatin compositions having anti-ulcer activities | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1988-10-25 | — | — | US | disclosed |
| US-4639524-A | ANTIARRHYTHMIA AGENTS | G. D. SEARLE & CO. (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0205299-A2 | Isatin derivatives, compositions containing the same, and the use thereof for ulcer diseases | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |
| EP-0170901-A1 | Monobasic disobutamide derivatives | G.D. Searle & Co. (US) | 1986-02-12 | — | — | EP | disclosed |