Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11205275 | 0.83 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2KDM4EGAAMEN1 | |
| SCHEMBL11206996 | 0.83 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL31560779 | 0.83 | AKR1B1 (0.47) | MAPTSMN1; SMN2KDM4EGAAKMT2A | |
| SCHEMBL11202760 | 0.82 | KCNA5 (0.42) | MAPTSMN1; SMN2KCNA5KDM4EGAA | |
| SCHEMBL24303078 | 0.80 | NPC1 (0.49) | MAPTSMN1; SMN2KCNA5KDM4EGAA | |
| SCHEMBL9904777 | 0.78 | KCNA5 (0.46) | MAPTSMN1; SMN2KCNA5KDM4EGAA | |
| SCHEMBL75124 | 0.78 | MAPT (0.62) | MAPTSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL11209347 | 0.78 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2KCNA5KDM4EGAA | |
| Methyl Alcohol SCHEMBL11211940 | 0.75 | MAPT (0.63) | MAPTSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL10396077 | 0.75 | BID (0.43) | MAPTSMN1; SMN2KDM4EALDH1A1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |
| EP-0094833-A2 | Novel 1,2-benzisoxazole derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1983-11-23 | — | — | EP | disclosed |