Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL11211940 | 0.97 | MAPT (0.63) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| Toluene SCHEMBL11204804 | 0.92 | MAPT (0.67) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| Benzyl Alcohol SCHEMBL11208104 | 0.91 | MAPT (0.54) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL4907408 | 0.91 | LMNA (0.55) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5697386 | 0.87 | MAPT (0.53) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL10916558 | 0.86 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL2793131 | 0.84 | LMNA (0.58) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL10242664 | 0.84 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL28603039 | 0.83 | RAB9A (0.64) | MAPTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL6997107 | 0.83 | LMNA (0.53) | MAPTSMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 402 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1728786-B1 | ONE-POT PROCESS FOR PRODUCING 1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2016-01-13 | — | — | EP | claimed |
| CN-1934096-B | Single-pot preparation method of 1, 2-benzisoxazole-3-methyl sulfonamide | DAINIPPON SUMITOMO PHARMA CO | 2012-04-18 | — | — | CN | claimed |
| CN-101263128-B | Sulfonation method of 1, 2-benzisoxazole-3-acetic acid | DAINIPPON SUMITOMO PHARMA CO | 2011-02-16 | — | — | CN | claimed |
| CN-101263128-A | Sulfonation method of 1, 2-benzisoxazole-3-acetic acid | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-09-10 | — | — | CN | claimed |
| EP-1935888-A1 | METHOD FOR SULFONATING 1,2-BENZISOXAZOLE-3-ACETIC ACID | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-06-25 | — | — | EP | claimed |
| US-7268234-B2 | Method for sulfonation of 1,2-benzisoxazole-3-acetic acid | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-09-11 | — | — | US | claimed |
| US-7262304-B2 | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-08-28 | — | — | US | claimed |
| US-20070066830-A1 | METHOD FOR SULFONATION OF 1,2-BENZISOXAZOLE-3-ACETIC ACID | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-03-22 | — | — | US | claimed |
| CN-1934096-A | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide | DAINIPPON SUMITOMO PHARMA CO (JP) | 2007-03-21 | — | — | CN | claimed |
| US-20060287535-A1 | Process for the manufacture of 1,2-benzisoxazole-3-methanesulphonamide | WOCKHARDT LIMITED | 2006-12-21 | — | — | US | claimed |
| EP-1728786-A1 | ONE-POT PROCESS FOR PRODUCING 1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2006-12-06 | — | — | EP | claimed |
| US-20060229454-A1 | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide | Sumitomo Pharma Co., Ltd. (JP) | 2006-10-12 | — | — | US | claimed |
| US-7081539-B2 | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2006-07-25 | — | — | US | claimed |
| US-20060084814-A1 | Process for the preparation of zonisamide | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-04-20 | — | — | US | claimed |
| US-20050215796-A1 | One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide | Sumitomo Pharma Co., Ltd. (JP) | 2005-09-29 | — | — | US | claimed |
| US-20040049053-A1 | Process for the prepartion of 1,2-benzisoxazole-3-acetic acid | MENDELOVICI MARIOARA (IL) | 2004-03-11 | — | — | US | claimed |
| US-6677458-B2 | REACTING 4-HYDROXY-COUMARIN WITH HYDROXYL-AMINE IN THE PRESENCE OF A BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-01-13 | — | — | US | claimed |
| US-20020183525-A1 | Process for the preparation of 1,2-benzisoxazole-3-acetic acid | TEVA PHARMACEUTICALS USA, INC. | 2002-12-05 | — | — | US | claimed |
| US-12534442-B2 | Benzisoxazole derivative | Sumitomo Pharma Co., Ltd. (JP) | 2026-01-27 | — | — | US | disclosed |
| EP-0063799-A2 | 1-(3-(6-fluoro-1,2-benzisoxasol-3-yl)propyl)-4-hydroxy-4-phenylpiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084814-A1 | Process for the preparation of zonisamide | CYP3A43, CYP3A4, CYP3A5 | MAPT 2606/4885SMN1; SMN2 3439/4885RAB9A 2154/4885 |
| US-20040049053-A1 | Process for the prepartion of 1,2-benzisoxazole-3-acetic acid | HAO2, CYP4X1, CYP2S1 | MAPT 4726/4885SMN1; SMN2 3728/4885RAB9A 4611/4885 |
| US-20020183525-A1 | Process for the preparation of 1,2-benzisoxazole-3-acetic acid | HAO2, CYP2S1, CYP4X1 | MAPT 4636/4885SMN1; SMN2 3094/4885RAB9A 4685/4885 |
| US-20060287535-A1 | Process for the manufacture of 1,2-benzisoxazole-3-methanesulphonamide | GABRE, CA3, GABRA1 | MAPT 1471/4885SMN1; SMN2 958/4885RAB9A 472/4885 |
| US-12534442-B2 | Benzisoxazole derivative | GABRA6, SLC6A1, GABRA1 | MAPT 2827/4885SMN1; SMN2 1568/4885RAB9A 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.