Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207898 | 0.86 | KDM4E (0.42) | SMN1; SMN2MAPTGAACYP1A2CYP3A4 | |
| SCHEMBL11205275 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTAKR1B1GAANPC1 | |
| SCHEMBL11211516 | 0.78 | MAPT (0.50) | SMN1; SMN2MAPTAKR1B1GAACYP1A2 | |
| SCHEMBL10396077 | 0.77 | BID (0.43) | SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL31560779 | 0.77 | AKR1B1 (0.47) | SMN1; SMN2MAPTAKR1B1GAARAB9A | |
| SCHEMBL11206996 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTAKR1B1GAANPC1 | |
| SCHEMBL75124 | 0.72 | MAPT (0.62) | SMN1; SMN2MAPTGAACYP3A4NPC1 | |
| Benzyl Alcohol SCHEMBL11208104 | 0.71 | MAPT (0.54) | SMN1; SMN2MAPTAKR1B1GAACYP3A4 | |
| SCHEMBL11207216 | 0.71 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTPTGDR2GAANPC1 | |
| SCHEMBL23640271 | 0.70 | MAPT (0.46) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094833-A2 | Novel 1,2-benzisoxazole derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1983-11-23 | — | — | EP | disclosed |