Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28944629 | 0.94 | TDP1 (0.59) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL11865237 | 0.94 | TDP1 (0.59) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL5937453 | 0.92 | TDP1 (0.56) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL28328052 | 0.87 | TDP1 (0.50) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL28118329 | 0.85 | TDP1 (0.62) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL28317518 | 0.85 | TDP1 (0.62) | TDP1CA1CA2TSHRLMNA | |
| Propylene Glycol SCHEMBL2538043 | 0.84 | — | — | |
| Propylene Glycol SCHEMBL28743699 | 0.82 | TDP1 (0.59) | TDP1CA1CA2TSHRLMNA | |
| Glycerin SCHEMBL28811950 | 0.82 | LMNA (0.53) | TDP1CA1LMNACA4ALDH1A1 | |
| Propylene Glycol SCHEMBL29023668 | 0.82 | TDP1 (0.59) | TDP1CA1CA2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58217778-A | — | — | None | — | — | JP | disclosed |
| JP-S58217778-A | INTERNAL-COMBUSTION ENGINE | MITSUBISHI HEAVY IND LTD | 1983-12-17 | — | — | JP | disclosed |