Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28317518 | 0.94 | TDP1 (0.62) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL29023668 | 0.91 | TDP1 (0.59) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL11865237 | 0.91 | TDP1 (0.59) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL5937453 | 0.88 | TDP1 (0.56) | TDP1CA2LMNACA1TSHR | |
| Cadaverine Tartrate SCHEMBL6413510 | 0.86 | LMNA (0.54) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL28944629 | 0.85 | TDP1 (0.59) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL11215067 | 0.85 | TDP1 (0.59) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL28743699 | 0.85 | TDP1 (0.59) | TDP1CA2LMNACA1TSHR | |
| Propylene Glycol SCHEMBL28866018 | 0.80 | TDP1 (0.53) | TDP1CA2CA1TSHRCA4 | |
| Propylene Glycol SCHEMBL28574118 | 0.80 | TDP1 (0.71) | TDP1CA2CA1TSHROR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106179349-A | A kind of preparation method and applications of ultra-fine nano Co B catalyst | 天津大学 | 2016-12-07 | — | — | CN | disclosed |